Welcome to OrgMedChem Research Group

We are a research group of organic chemistry and medicinal chemistry, dedicated to innovation and excellence in research. Our team is committed to making groundbreaking discoveries that push the boundaries of science and improve human health. Click here to learn more about our team and our work.

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Our Research Focus

At OrgMedChem, our research is driven by a passion for advancing the fields of organic chemistry and medicinal chemistry. We are dedicated to pushing the boundaries of scientific knowledge and leveraging our expertise to develop new and improved methods for addressing complex challenges in chemistry. Our team is committed to making a meaningful impact on the future of science and medicine through our innovative research endeavors.

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Latest Research Publications

Stereochemistry-Guided Switch from Irreversible to Slow-Binding Cathepsin L Inhibition

In this work, we present the design, synthesis, and mechanistic investigation of two epoxyketone-based dipeptidyl CatL inhibitors (D1 and D2) and two azido-based derivatives (AZA and AMK). From a combination of experimental and computational studies, we have demonstrated the importance of epoxide stereochemistry and azido functionality in determining the mode of inhibition and reactivity.

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